Serum anion gap with optional albumin adjustment
Used for: Clinical interpretation of serum/plasma electrolytes using the reporting laboratory's anion-gap convention
JJ
Laboratory methods
James J. Figge
Research profile. James J. Figge is not affiliated with or endorsed by MedMaths.
Endocrinology and quantitative acid-base physiology
Serum anion gap with optional albumin adjustment
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Overview
James J. Figge, MD, MBA, is an endocrinologist and acid-base researcher whose work has examined the quantitative role of albumin and other weak acids in human acid-base physiology. He was first author of the 1998 Critical Care Medicine study ‘Anion gap and hypoalbuminemia,’ which quantified how changes in albumin alter the observed anion gap and derived a 2.5 mEq/L per 1 g/dL albumin adjustment relationship. This work concerns albumin adjustment of the anion gap; it did not invent the standard sodium-minus-chloride-and-bicarbonate arithmetic.
- Specialty
- Endocrinology and quantitative acid-base physiology
- Institutions
- St. Peter's Health Partners, Albany, New York (published affiliation)
Formula history
Research contributions
Evidence trail
Original research
Figge J, Jabor A, Kazda A, Fencl V. Anion gap and hypoalbuminemia. Critical Care Medicine. 1998;26(11):1807-1810
This paper quantified how abnormal albumin changes the observed anion gap and derived the 0.25 mEq/L per g/L (2.5 mEq/L per g/dL) adjustment relationship. It should not be described as the invention of standard anion-gap arithmetic.
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Reference data verified: 2026-08-24
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