Research profile. R. Brian Payne is not affiliated with or endorsed by MedMaths.
Chemical pathology and clinical biochemistry
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R. Brian Payne is a clinical biochemist and chemical pathologist associated with St James's University Hospital in Leeds. He was lead author of the 1973 British Medical Journal paper that described an albumin-based adjustment of total serum calcium, work that became highly influential in the history of ‘corrected calcium.’ He has continued to publish on the interpretation and limitations of albumin-adjusted calcium.
Evidence trail
Payne RB, Little AJ, Williams RB, Milner JR. Payne RB, Little AJ, Williams RB, Milner JR — Interpretation of serum calcium in patients with abnormal serum proteins. British Medical Journal. 1973;4(5893):643-646
Historical source for the original Payne albumin-adjustment work. The MedMaths corrected-calcium calculator uses the later commonly used simplified 0.02 × (40 − albumin) equation, not the original 1973 regression equation.
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A. J. Little was a co-author of the 1973 British Medical Journal study “Interpretation of serum calcium in patients with abnormal serum proteins.” That study analyzed the relationship between serum calcium and albumin and derived an albumin-adjustment equation. Reliable biographical detail identifying this author beyond the publication record is limited, so MedMaths deliberately restricts this profile to the contribution that can be verified from the paper.
R. B. Williams was a co-author of the 1973 British Medical Journal study “Interpretation of serum calcium in patients with abnormal serum proteins.” The paper helped establish an albumin-based method for interpreting total serum calcium. Because authoritative biographical information that uniquely identifies this author is limited, this MedMaths profile does not infer credentials or appointments beyond the verified publication record.
J. R. Milner was a co-author of the 1973 British Medical Journal study “Interpretation of serum calcium in patients with abnormal serum proteins.” The study used clinical laboratory specimens to examine the relationship between calcium and serum proteins and derived an albumin-adjustment equation. MedMaths limits this profile to that verified contribution because a definitive authoritative biography for this specific author has not been established.
This profile summarizes the published work and draws on the original publications above and verified external sources. It isn't a calculator or clinical advice. R. Brian Payne isn't affiliated with MedMaths and hasn't endorsed it. Anything we couldn't confirm is left blank, not estimated.
Reference data verified: 2026-08-11
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