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Lesson overview

Medication Dilution Calculations: C₁V₁ = C₂V₂

Learn what happens when the same amount of medicine is spread through more liquid, then use C1V1 = C2V2 to find a missing concentration or volume.
About 24 minutesMedication PreparationNo account required

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Created by George Lambroglou, RN

Founder-led review of formulas, worked examples and safety text · Last reviewed 18 September 2026

MethodologyEditorial policy

Learning outcomes

What you will learn

  • explain dilution in plain English
  • tell medication amount, liquid volume and concentration apart
  • distinguish ‘dilute to’ / ‘final volume’ wording from ‘dilute with’ / ‘add’, while recognising ‘make up to’ wording
  • explain what C1, V1, C2 and V2 mean
  • calculate any one missing C1V1 = C2V2 value when the other three are known
  • recognise that C1 and C2 must use a compatible concentration basis rather than assuming every percent strength is interchangeable
  • use a new concentration for a later mg → mL calculation
  • recognise when a result does not make sense for an ordinary dilution

Clinical connection

Why this matters

A dilution error can start with something as simple as confusing the starting volume with the final total volume, or reading ‘make up to’ as ‘add’. Giving every number one clear job makes the equation much easier to use correctly.

Quick concept

How C₁V₁ = C₂V₂ works for medication dilution

In a simple dilution relationship, the amount of the same medicine or solute carried forward is unchanged while concentration and total volume change. Use compatible concentration units on both sides, and remember that V₂ is the final total volume, not automatically the amount of diluent added.

Formula

C₁ × V₁ = C₂ × V₂

Worked example

Educational example: 100 mg/mL stock is used to prepare a verified final concentration of 20 mg/mL in a verified final total volume of 50 mL.

V₁ = (20 × 50) ÷ 100 = 10 mL

Answer: 10 mL of the stated stock solution is required mathematically

C₁V₁ = C₂V₂ checks concentration-volume arithmetic only. It does not decide whether a medicine may be diluted, which diluent to use, compatibility, stability, concentration limits, route, aseptic process or administration instructions.

Lesson plan

How the lesson works

  1. 1

    Learn

    Short teaching slides explain one idea at a time with plain-language examples.

  2. 2

    Practise

    Answer calculation or scenario questions and receive immediate feedback.

  3. 3

    Finish

    Complete the lesson check and save your learning progress on this browser.

Keep going

Learn, practise, apply and check this skill

Use the page that matches what you need next. Each resource has a different job, so the lesson can stay focused on teaching the skill.

Practise

Medication dilution practice questions

Practise C₁V₁ = C₂V₂, final-volume wording and concentration checks across four levels.

Understand

C₁V₁ = C₂V₂ explained

Review why the equation works, what each value means and the dilute-to versus dilute-with distinction.

Check

Medication Dilution Calculator

Solve for one missing verified concentration or volume value in C₁V₁ = C₂V₂.

Apply

Medication & IV Safety cases

Use preparation and concentration arithmetic inside realistic medication scenarios.

Back to Medication Preparation

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