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Clinical chemistry
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Leslie Chalmers was a clinical chemistry researcher at the William Pepper Laboratory, Division of Chemistry, Hospital of the University of Pennsylvania. Chalmers co-authored the 1975 Clinical Chemistry paper with William V. Dorwart that compared 13 approaches to calculated serum osmolality and evaluated how closely calculated values agreed with measured osmolality.
Evidence trail
Dorwart WV, Chalmers L. Dorwart WV, Chalmers L — Comparison of methods for calculating serum osmolality from chemical concentrations, and the prognostic value of such calculations. Clinical Chemistry. 1975;21(2):190-194
Research-history record for calculated serum osmolality. No calculator relationship is implied unless separately verified.
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William V. Dorwart was a clinical chemistry researcher at the William Pepper Laboratory, Division of Chemistry, Hospital of the University of Pennsylvania. With Leslie Chalmers, he published a 1975 Clinical Chemistry study comparing multiple methods for calculating serum osmolality from measured chemical concentrations. The study analysed 715 hospital-patient serum samples and proposed an equation that closely matched measured osmolality.
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Reference data verified: 2026-08-11
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