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Clinical chemistry
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William V. Dorwart was a clinical chemistry researcher at the William Pepper Laboratory, Division of Chemistry, Hospital of the University of Pennsylvania. With Leslie Chalmers, he published a 1975 Clinical Chemistry study comparing multiple methods for calculating serum osmolality from measured chemical concentrations. The study analyzed 715 hospital-patient serum samples and proposed an equation that closely matched measured osmolality.
Evidence trail
Dorwart WV, Chalmers L. Dorwart WV, Chalmers L — Comparison of methods for calculating serum osmolality from chemical concentrations, and the prognostic value of such calculations. Clinical Chemistry. 1975;21(2):190-194
Research-history record for calculated serum osmolality. No calculator relationship is implied unless separately verified.
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Leslie Chalmers was a clinical chemistry researcher at the William Pepper Laboratory, Division of Chemistry, Hospital of the University of Pennsylvania. Chalmers co-authored the 1975 Clinical Chemistry paper with William V. Dorwart that compared 13 approaches to calculated serum osmolality and evaluated how closely calculated values agreed with measured osmolality.
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Reference data verified: 2026-08-11
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