Smithline-Gardner Calculated Serum Osmolality Formula
Equation attributed to Neil Smithline.
Used for: Clinical estimation of serum/plasma osmolality from sodium, glucose and urea/BUN measurements
NS
Laboratory methods
Neil Smithline
Research profile. Neil Smithline is not affiliated with or endorsed by MedMaths.
Renal medicine
Smithline-Gardner Calculated Serum Osmolality Formula
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Overview
Neil Smithline, MD, was affiliated with the Department of Medicine, Renal Section, University of Arizona College of Medicine and the Veterans Administration Hospital in Tucson when he co-authored the 1976 JAMA article ‘Gaps—Anionic and Osmolal.’ The paper described the bedside use of anion and osmolal gaps and is associated with the simple calculated-serum-osmolality equation used by MedMaths. This profile is deliberately limited to details verified from the original publication record.
- Specialty
- Renal medicine
- Institutions
- University of Arizona College of Medicine; Veterans Administration Hospital, Tucson
Formula history
Research contributions
Evidence trail
Original research
Smithline N, Gardner KD Jr. Smithline N, Gardner KD Jr — Gaps—Anionic and Osmolal. JAMA. 1976;236(14):1594-1597
Historical source for the 1976 Smithline-Gardner bedside osmolal-gap framework associated with the simple calculated-osmolality equation used by MedMaths. This attribution is not a claim that the authors were the first to calculate serum osmolality.
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Smithline-Gardner Calculated Serum Osmolality Formula
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This source-based research reference profile draws on the original publications above and verified external sources. Neil Smithline is not affiliated with or endorsed by MedMaths. Unconfirmed fields are left blank rather than estimated.
Reference data verified: 2026-08-12
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