Hillier hyperglycaemia sodium correction (2.4 overall estimate)
Based on research published by Eugene J. Barrett.
Used for: Alternative empirical estimate of the acute sodium-glucose relationship during experimentally induced hyperglycaemia
EJ
Laboratory methods
Eugene J. Barrett
Research profile. Eugene J. Barrett is not affiliated with or endorsed by MedMaths.
Endocrinology and metabolism
Hillier hyperglycaemia sodium correction (2.4 overall estimate)
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Overview
Eugene J. Barrett, MD, PhD, is an endocrinologist and Professor of Medicine at the University of Virginia whose research has focused on insulin action, insulin resistance and microvascular physiology. He co-authored the 1999 Hillier study that experimentally evaluated the sodium-glucose correction factor during acute hyperglycaemia. His University of Virginia profile also identifies him as a past president of the American Diabetes Association.
- Specialty
- Endocrinology and metabolism
- Institutions
- University of Virginia School of Medicine; UVA Diabetes Center
Formula history
Research contributions
Evidence trail
Original research
Hillier TA, Abbott RD, Barrett EJ. Hillier TA, Abbott RD, Barrett EJ — Hyponatremia: evaluating the correction factor for hyperglycemia. American Journal of Medicine. 1999;106(4):399-403
Experimental study in six healthy subjects reporting a mean overall sodium change of 2.4 mmol/L per 100 mg/dL glucose change and a non-linear relationship at very high glucose concentrations; 2.4 is presented by MedMaths as the study's overall estimate, not a universal constant.
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TA
Known for
Hillier hyperglycaemia sodium correction (2.4 overall estimate)
1 publication 1 linked calculatorProfile
RD
Known for
Hillier hyperglycaemia sodium correction (2.4 overall estimate)
1 publication 1 linked calculatorProfile
About this profile
This profile summarizes the published work and draws on the original publications above and verified external sources. It isn't a calculator or clinical advice. Eugene J. Barrett isn't affiliated with MedMaths and hasn't endorsed it. Anything we couldn't confirm is left blank, not estimated.
Reference data verified: 2026-08-12
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